Sesntrin2 Modulates AMPK Signaling Image Long Description

Overview

Sesn2 is a critical factor in aged-related adaptive response to ischemia and reperfusion stress. Through maintaining the cellular redox homeostasis, thus modulating inflammation response, Sesn2 facilitates the heart to adapt to the ischemic injury. Therefore, Sesn2 could be a potential pharmacological target for developing the new therapeutic strategies of the cardiac diseases, especially for the aging population.

Presentation

The graphic has four rectangles aligned in a square. The top two are smaller than the bottom two. The rectangles on the left are light blue, and the ones on the right are pink. Between each row of rectangles is an illustration of a human heart. The second heart illustration has a dark area at the bottom with the labels LAD and Ischemia/Reperfusion.

• Top left light blue rectangle: Title of Young with the text Anti-Longevity genes followed by a right tack symbol and the text Pro-Longevity genes followed by a left arrow. Next to the words are two green ovals with the term Sesn2 in each.
• Top right pink rectangle: Title of Aged with a green oval containing the term Sesn2, the left tack symbol followed by the text Anti-Longevity genes and a right arrow followed by the text Pro-Longevity genes.
• Bottom light blue and pink rectangles: Mirror images of the following except for two Sesn2 ovals and a diagonal right tack symbol on the left and one Sesn2 oval with a diagonal left tack symbol on the right:
  • A seven-point star (slightly larger in the bottom right rectangle) with the label ROS has an arrow pointing to a blue rectangle with the label p38.
  • Another arrow from ROS points to a green rectangle with the term JNK. Both rectangles have a dark yellow circle with the letter P on the top right corner.
  • A purple oval with the label IL-17 is next to the rectangles with an arrow pointing back at them.
  • Below the rectangles in an arrow pointing to a beige oval containing a strand of DNA and a black rectangle with the label NF-κB and a dark yellow circle with a P in it on the top right corner of the rectangle.
  • An angled arrow points from the DNA to the text IL-1β, IL-6, IFN-γ, TNF-α. An arrow pointing from this text points to a red rectangle with the label Promoting inflammation, and an arrow from this rectangle points to the aforementioned IL-17 purple oval.
  • Between each rectangle is an illustration of mitochondria with left and right arrows on the sides, each pointing back to the seven-point star with the ROS label.

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